Colloidal gels are particularly promising injectable biomaterials for tissue engineering due to outstanding properties. These gels are solely composed of colloidal nano/micro particles, which can be loaded or functionalized with different types of drugs or biomolecules. In our group, we have developed new colloidal composite biomaterials for treatment of bone diseases, e.g. bone cancer, bone infections. These promising findings sitimulate us to continue upscaling particles production in a controlled process and quality.
To study the feasibility of scale-up process, we are looking for interns who can support us in the following tasks:
- Replicate synthesis of gelatin (type A and type B) nanoparticles in lab scale
- Define quality assurance for lab scale
- Define quality control for lab scale
- Colloidal gels formation with opposite charged gelatin type A and type B nanoparticles
- Rheological properties of colloidal gels
- Semi-upscalling feasibility study for both nanoparticles (10~100 g)
- Summary Report
More specifically, your responsibilities:
- Realize protocol in lab sacle and confirm reproducibility
- Characterization of nanoparticles and colloidal gels, e.g. Dynamic light scattering (DLS), Scanning electron microscopy (SEM), FTIR, Rheometer, etc.
- Optimize process for controbility of nanoparticles in order to eliminate batch-to-batch variations
- Define QA/QC parameters in order to evaluate quality of nanoparticles
- Maximizing the yield of the synthesis without compromising the quality
- Deliver progress report to project supervisors
This internship encourages you to work with acedemia professionals, as well as industrial partners. Students with (organic) chemistry, chemical engineering, nano/micro-medicine, biomaterials, QA/QC background are prompted to apply.